MICRONIZED EUTECTIC MIXTURE OF FENOFIBRIC ACID-SACCHARIN FORMATION FOR SOLUBILITY AND DISSOLUTION ENHANCEMENT

Authors

  • USWATUL HASANAH Department of Pharmaceutics, Faculty of Pharmacy, Universitas Andalas, Padang, West Sumatra, 25163, Indonesia
  • LIZA WAHYUNI Department of Pharmaceutics, Faculty of Pharmacy, Universitas Andalas, Padang, West Sumatra, 25163, Indonesia
  • ERIZAL ZAINI Department of Pharmaceutics, Faculty of Pharmacy, Universitas Andalas, Padang, West Sumatra, 25163, Indonesia

DOI:

https://doi.org/10.22159/ijap.2023.v15s1.47514

Keywords:

Dissolution enhancement, Eutectic mixture, Fenofibric acid, Microparticles, Saccharin, Spray drying

Abstract

Objective: This study aims to increase the solubility and dissolution rate of fenofibric acid by forming a micronized eutectic mixture of fenofibric acid-saccharin with spray drying technique.

Methods: Suspension of the eutectic mixture was prepared in ethanol: distilled water (3:1) followed by a spray drying method to obtain the microparticles. Microparticles characterization was performed by particle size analysis (PSA), powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), FT-IR spectroscopy, and scanning electron microscopy (SEM). Solubility test was carried out in CO2-free distilled water, meanwhile the dissolution rate study was conducted in phosphate buffer solution at pH 6.8.

Results: The results showed the mean of the samples’ particle size was 72.29±7.33 µm. Compared to the intact fenofibric acid, the micronized eutectic mixture sample has a decreased melting point, fusion enthalpy, and crystallinity without any wavenumber shifted in the FT-IR spectra. The solubility of micronized eutectic mixture was 2.2 times higher than intact fenofibric acid, while the amount of micronized eutectic mixture dissolved at 60 min was 11.7 times higher.

Conclusion: It can be concluded that the spray-dried micronized eutectic mixture of fenofibric acid-saccharin was having the ability to enhance the dissolution of fenofibric acid.

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Published

07-02-2023

How to Cite

HASANAH, U., WAHYUNI, L., & ZAINI, E. (2023). MICRONIZED EUTECTIC MIXTURE OF FENOFIBRIC ACID-SACCHARIN FORMATION FOR SOLUBILITY AND DISSOLUTION ENHANCEMENT. International Journal of Applied Pharmaceutics, 15(1), 56–60. https://doi.org/10.22159/ijap.2023.v15s1.47514

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