ENHANCEMENT OF CURCUMIN SOLUBILITY AND DISSOLUTION BY ADSORPTION IN MESOPOROUS SBA-15

LILI FITRIANI; HUSNUN AZIZAH; USWATUL HASANAH; ERIZAL ZAINI

doi:10.22159/ijap.2023.v15s1.47515

Authors

LILI FITRIANI Department of Pharmaceutics, Faculty of Pharmacy, Universitas Andalas, Kampus Limau Manis, Padang 25163
HUSNUN AZIZAH Department of Pharmaceutics, Faculty of Pharmacy, Universitas Andalas, Kampus Limau Manis, Padang 25163
USWATUL HASANAH Department of Pharmaceutics, Faculty of Pharmacy, Universitas Andalas, Kampus Limau Manis, Padang 25163
ERIZAL ZAINI Department of Pharmaceutics, Faculty of Pharmacy, Universitas Andalas, Kampus Limau Manis, Padang 25163

DOI:

https://doi.org/10.22159/ijap.2023.v15s1.47515

Keywords:

Curcumin, SBA-15, Solubility, Dissolution rate

Abstract

Objective: Curcumin belongs to BCS class IV, which has low solubility, around 7.8 µg/ml and its results of low bioavailability. The study aimed to enhance solubility and dissolution rate of curcumin by adsorption in mesoporous silica SBA-15.

Methods: The synthesis of SBA-15 was done by using tetraethyl orthosilicate (TEOS) as silica precursors and Pluronic P123 (EO20PO70EO20) as template of pore-forming. Impregnation of curcumin in SBA-15 was conducted by evaporation in ethanol solution with 2:1 of curcumin: SBA-15 proportion. Curcumin-SBA-15 were characterized by Nitrogen Adsorption-Desorption Isotherm, Powder X-Ray Diffraction (PXRD), Fourier Transformed Infrared (FT-IR), Differential Scanning Calorimetry (DSC), and Scanning Electron Microscopy (SEM). The solubility test was performed by using an orbital shaker for 24 h in CO₂-free distilled water. The dissolution rate was conducted in CO₂-free distilled water using USP Type-II dissolution test apparatus.

Results: Efficiency entrapment of curcumin-SBA-15 was 59.433%. The successful adsorption of curcumin in SBA-15 was confirmed by reducing its surface area (48.165 m²/g) and pore volume (0.073x10-¹ cm³/g). The results of PXRD analysis showed that decreased in the intensity of the diffraction peak. In addition, the FTIR spectrum of curcumin-SBA-15 was similar to its intact component. The solubility and dissolution rate test of curcumin-SBA-15 enhanced 2.201 times and 3.214 times at 60 min compared to intact curcumin.

Conclusion: It can be concluded that the adsorption of curcumin in SBA-15 increased both the solubility and dissolution rate of curcumin.

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